CSF Levels of Angiopoietin-2 Do Not Differ between Patients with CSF Fluid Leakage Syndrome and ControlsReport as inadecuate




CSF Levels of Angiopoietin-2 Do Not Differ between Patients with CSF Fluid Leakage Syndrome and Controls - Download this document for free, or read online. Document in PDF available to download.

Disease Markers - Volume 2015 2015, Article ID 343818, 9 pages -

Research Article

Department of Neurology, Hannover Medical School, Carl-Neuberg-Straße 1, 30625 Hannover, Germany

Department of Neuroradiology, Hannover Medical School, Carl-Neuberg-Straße 1, 30625 Hannover, Germany

Department of Nuclear Medicine, Hannover Medical School, Carl-Neuberg-Straße 1, 30625 Hannover, Germany

Received 9 May 2015; Revised 24 August 2015; Accepted 25 August 2015

Academic Editor: Natacha Turck

Copyright © 2015 Refik Pul et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

CSF abnormalities have been reported in CSF leakage syndrome. However, the mechanism for these CSF changes is actually unknown and they may indicate impaired CSF flow or blood-CSF barrier. Angiopoietin-2 Ang-2, a protein which is expressed and released by endothelial cells, has been associated with increased vascular permeability. In the assumption that CSF changes are due to an impaired blood-CSF barrier, we hypothesized that subjects with persistent CSF leakage may have increased CSF Ang-2 levels. We enrolled 10 subjects with a clinically definite diagnosis of persisting CSF leakage syndrome and 10 control subjects. In CSF analyses, CSF to serum albumin ratio Qalb was the most frequently increased parameter indicating a disturbed blood-CSF barrier function. Comparison of the mean CSF Ang-2 levels, CSF to serum Ang-2 ratio QAng-2, and QAng-2-Qalb between the control and CSF leakage patients did not show any significant difference. We suggest that the increase of Qalb results from a low CSF flow. Future studies with phase contrast-MRI in conjunction with CSF analyses before and after epidural blood patch treatment are required to address this question. It would be of particular interest whether Qalb can be used as a marker for successful nontargeted epidural blood patch treatment.





Author: Refik Pul, Özlem Yildiz, Franco Morbiducci, Thomas Skripuletz, Philipp Schwenkenbecher, Martin Stangel, Friedrich Götz, G

Source: https://www.hindawi.com/



DOWNLOAD PDF




Related documents