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Journal of Translational Medicine

, 2:11

First Online: 08 April 2004Received: 24 February 2004Accepted: 08 April 2004DOI: 10.1186-1479-5876-2-11

Cite this article as: thor Straten, P., Schrama, D., Andersen, M.H. et al. J Transl Med 2004 2: 11. doi:10.1186-1479-5876-2-11

Abstract

Cells of the immune system spontaneously recognize autologous tumor cells and T cells are believed to be the main effector cells for the immune surveillance of cancer. Recent advances in our understanding of basic and tumor immunology together with methodological developments implies that tumor specific T cells can now be studied functionally, phenotypically as well as molecularly. T cells recognize peptide antigens in the context of MHC molecules through the clonally distributed T-cell receptor TCR, thus, the clonal distribution of the TCR offers the means to detect and track specific T cells based upon detection of the unique TCR. In this review, we present and discuss available data on TCR utilization of tumor specific T cells in murine models as well as spontaneous and treatment induced anti-tumor T-cell responses in humans.

List of abbreviationsBVBeta variable

DGGEdenaturing gradient gel electrophoresis

TCRT-cell receptor

TILtumor infiltrating lymphocyte

IL-2interleukin-2

CTLcytotoxic T lymphocyte

DNPdinitrophenyl

CDR3complementarity-determining region 3





Author: Per thor Straten - David Schrama - Mads Hald Andersen - Jürgen C Becker

Source: https://link.springer.com/



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