Lactobacillus acidophilus Suppresses Colitis-Associated Activation of the IL-23-Th17 AxisReport as inadecuate




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Journal of Immunology Research - Volume 2015 2015, Article ID 909514, 10 pages -

Research Article

Department of Gastroenterology, Xiangya Hospital of Central South University, Changsha 410011, China

Department of Gastroenterology, Second Xiangya Hospital of Central South University, Changsha 410008, China

Received 30 June 2014; Revised 10 September 2014; Accepted 18 September 2014

Academic Editor: Lenin Pavon

Copyright © 2015 Linlin Chen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The aim of this paper is to determine the modulatory effects of Lactobacillus acidophilus on the IL-23-Th17 immune axis in experimental colitis. DSS-induced mouse models of UC were to be saline, hormones, and different concentrations of Lactobacillus acidophilus intervention. The expression of interleukin- IL- 17, tumor necrosis factor α TNFα, IL-23, transforming growth factor β1 TGFβ1, signal transducer and activator of transcription 3 STAT3, and phosphorylated p-STAT3 was examined by RT-PCR, Western blotting, and immunohistochemical analysis. And the results showed that administration of L. acidophilus suppressed Th17 cell-mediated secretion of proinflammatory cytokine IL-17 through downregulation of IL-23 and TGFβ1 expression and downstream phosphorylation of p-STAT3.





Author: Linlin Chen, Yiyou Zou, Jie Peng, Fanggen Lu, Yani Yin, Fujun Li, and Junwen Yang

Source: https://www.hindawi.com/



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