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Genome Medicine

, 9:25

First Online: 21 March 2017DOI: 10.1186-s13073-017-0423-3

Cite this article as: Polimanti, R., Agrawal, A. & Gelernter, J. Genome Med 2017 9: 25. doi:10.1186-s13073-017-0423-3 Editorial summary

Dual diagnosis with substance use disorders SUDs consistently contributes to the premature mortality and increased disability observed in schizophrenia. Large genome-wide association studies are providing the information needed to investigate the genetic architecture of psychiatric disorders. Here, we discuss recent genetic investigations of dual diagnosis i.e., schizophrenia plus a SUD and how these findings can inform public health messages.

AbbreviationsGWASgenome-wide association studies

MRmendelian randomization

ORodds ratio

PRSpolygenic risk score

SUDsubstance use disorder





Author: Renato Polimanti - Arpana Agrawal - Joel Gelernter

Source: https://link.springer.com/







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