Microwave-Assisted Synthesis and Biological Evaluation of Dihydropyrimidinone Derivatives as Anti-Inflammatory, Antibacterial, and Antifungal AgentsReport as inadecuate




Microwave-Assisted Synthesis and Biological Evaluation of Dihydropyrimidinone Derivatives as Anti-Inflammatory, Antibacterial, and Antifungal Agents - Download this document for free, or read online. Document in PDF available to download.

International Journal of Medicinal ChemistryVolume 2013 2013, Article ID 197612, 5 pages

Research ArticleLaboratory of Heterocycles, School of Studies in Chemistry and Biochemistry, Vikram University, Ujjain, Madhya Pradesh 456010, India

Received 25 October 2012; Revised 31 January 2013; Accepted 17 March 2013

Academic Editor: Qidong You

Copyright © 2013 Anjna Bhatewara et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

A simple protocol for the efficient preparation of aryl and heteroaryl substituted dihydropyrimidinone has been achieved via initial Knoevenagel, subsequent addition, and final cyclization of aldehyde, ethylcyanoacetate, and guanidine nitrate in the presence of piperidine as a catalyst in solvent-free under microwave irradiation. The synthesized compounds showed a good anti-inflammatory, antibacterial, and antifungal activity.





Author: Anjna Bhatewara, Srinivasa Rao Jetti, Tanuja Kadre, Pradeep Paliwal, and Shubha Jain

Source: https://www.hindawi.com/



DOWNLOAD PDF




Related documents