Exploring the Functional Disorder and Corresponding Key Transcription Factors in Intraductal Papillary Mucinous Neoplasms ProgressionReport as inadecuate




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International Journal of Genomics - Volume 2015 2015, Article ID 197603, 9 pages -

Research Article

Department of Oncology, Tianjin Third Central Hospital, Tianjin 300179, China

Key Laboratory of Artificial Cell Institute of Hepatobiliary Disease, Tianjin Third Central Hospital, Tianjin 300179, China

Department of Hepatobiliary Surgery, Tianjin Third Central Hospital, Tianjin 300179, China

Received 18 June 2015; Accepted 11 August 2015

Academic Editor: Giulia Piaggio

Copyright © 2015 Guiying Bai et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

This study has analyzed the gene expression patterns of an IPMN microarray dataset including normal pancreatic ductal tissue NT, intraductal papillary mucinous adenoma IPMA, intraductal papillary mucinous carcinoma IPMC, and invasive ductal carcinoma IDC samples. And eight clusters of differentially expressed genes DEGs with similar expression pattern were detected by -means clustering. Then a survey map of functional disorder in IPMN progression was established by functional enrichment analysis of these clusters. In addition, transcription factors TFs enrichment analysis was used to detect the key TFs in each cluster of DEGs, and three TFs FLI1, ERG, and ESR1 were found to significantly regulate DEGs in cluster 1, and expression of these three TFs was validated by qRT-PCR. All these results indicated that these three TFs might play key roles in the early stages of IPMN progression.





Author: Guiying Bai, Chenxuan Wu, Yingtang Gao, and Guiming Shu

Source: https://www.hindawi.com/



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