The Physiopathological Role of IL-33: New Highlights in Bone Biology and a Proposed Role in Periodontal DiseaseReport as inadecuate




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Mediators of Inflammation - Volume 2014 2014, Article ID 342410, 8 pages -

Review Article

Institute of Biomedical Sciences, Laboratory of Immunoparasitology, Federal University of Uberlândia, Avenida Pará 1720, Building 2B, Room 2B22, CP 592, 38400-902 Uberlândia, MG, Brazil

Dentistry, Institute of Biomedical Sciences, Federal University of Uberlândia, CP 592, 38400-902 Uberlândia, MG, Brazil

Received 13 November 2013; Revised 3 January 2014; Accepted 6 January 2014; Published 18 February 2014

Academic Editor: Peter N. Pushparaj

Copyright © 2014 Felipe Andrés Cordero da Luz et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Interleukin-33 IL-33 is a recently described member of the IL-1 family. IL-33 acts as an alarmin, chemoattractant, and nuclear factor. ST2, a member of the Toll-like receptor-IL-1R superfamily, the receptor of IL-33, triggers a plethora of downstream effectors and leads the activation of NFK-B, leading the expression of several genes. IL-33 and ST2 are expressed in the majority of cell types, and the IL-33-ST2 axis has a role in immune response, bone homeostasis, and osteoclastogenesis. Several studies show opposite roles of IL-33 in osteoclastogenesis and the implication in bone biology. Few works studied the role of IL-33 in periodontal disease, but we hypothesize a possible role of IL-33 in periodontal disease and bone loss.





Author: Felipe Andrés Cordero da Luz, Ana Paula Lima Oliveira, Daniella Borges, Paula Cristina Brígido, and Marcelo José Barbosa Si

Source: https://www.hindawi.com/



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