Developmental Perturbation Induced by Maternal Asthma during Pregnancy: The Short- and Long-Term Impacts on OffspringReport as inadecuate




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Journal of PregnancyVolume 2012 2012, Article ID 741613, 8 pages

Review Article

Robinson Institute, University of Adelaide, Adelaide, SA 5005, Australia

Robinson Institute, University of Adelaide, Lyell McEwin Hospital, Haydown road, Elizabeth Vale, SA 5112, Australia

Discipline of Public Health, University of Adelaide, Adelaide, SA 5005, Australia

Mothers and Babies Research Centre, Hunter Medical Research Institute, University of Newcastle, NSW 2310, Australia

Received 5 April 2012; Accepted 6 June 2012

Academic Editor: Timothy Regnault

Copyright © 2012 Vicki L. Clifton et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Maternal asthma is a common disease to complicate human pregnancy. Epidemiological studies have identified that asthma during pregnancy increases the risk of a number of poor outcomes for the neonate including growth restriction, lower birthweight, preterm delivery, neonatal resuscitation, and stillbirth. Asthma therefore represents a significant health burden to society and could have an impact on the lifelong health of the children of women with asthma. Our research has identified that maternal asthma in pregnancy induces placental dysfunction and developmental perturbation in the fetus in a sex specific manner. These alterations in development could increase the risk of metabolic disease in adulthood of children of asthmatic mothers, especially females. In this paper, we will discuss the evidence currently available that supports the hypothesis that children of mothers with asthma may be at risk of lifelong health complications which include diabetes and hypertension.





Author: Vicki L. Clifton, Michael Davies, Vivienne Moore, Ian M. R. Wright, Zainab Ali, and Nicolette A. Hodyl

Source: https://www.hindawi.com/



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