Treatment Options for Metaplastic Breast CancerReport as inadecuate




Treatment Options for Metaplastic Breast Cancer - Download this document for free, or read online. Document in PDF available to download.

ISRN OncologyVolume 2012 2012, Article ID 706162, 4 pages

Review ArticleDivision of Surgical Oncology, UC Davis Comprehensive Cancer, Sacramento, CA 95817, USA

Received 11 April 2012; Accepted 21 May 2012

Academic Editors: P. Clavère, P. Karakitsos, M. Mandala, and C. Perez

Copyright © 2012 Dhruvil R. Shah et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Metaplastic breast cancer MBC is a malignancy characterized by the histologic presence of two or more cellular types, commonly a mixture of epithelial and mesenchymal components. MBC is rare relative to invasive ductal carcinoma IDC, representing less than 1% of all breast cancers. Other than a lower rate of lymph node metastases, MBC tumors display poorer prognostic features relative to IDC. Due to its low incidence and pathological variability, the ideal treatment paradigm for MBC is unknown. Because of its rarity, MBC has been treated as a variant of IDC. Despite similar treatment regimens, however, patients with MBC have worse outcomes. Recent research is focused on biological differences between MBC and IDC and potential novel targets for chemotherapeutic agents. This paper serves as a summation of current literature on approaches to the multidisciplinary treatment of patients with MBC.





Author: Dhruvil R. Shah, Warren H. Tseng, and Steve R. Martinez

Source: https://www.hindawi.com/



DOWNLOAD PDF




Related documents