A Validated RP – HPLC Method for Simultaneous Estimation of Cefixime and Cloxacillin in TabletsReport as inadecuate




A Validated RP – HPLC Method for Simultaneous Estimation of Cefixime and Cloxacillin in Tablets - Download this document for free, or read online. Document in PDF available to download.

E-Journal of Chemistry - Volume 5 2008, Issue 3, Pages 648-651



Department of Pharmaceutical Chemistry, Nandha College of Pharmacy, Erode-638 052, Tamilnadu, India

Department of Pharmaceutical Chemistry, Padmavathi College of Pharmacy, Dharmapuri, Tamilnadu, India

Received 2 December 2007; Revised 22 January 2008; Accepted 12 February 2008

Copyright © 2008 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

This paper presents a RP-HPLC method for the simultaneous estimation of cefixime and cloxacillin in tablets. The process was carried out on C18 column 5 μm, 25 cm × 4.6 mm, i.d using phosphate buffer pH 5.0, acetonitrile and methanol in the ratio 80:17:3 respectively as a mobile phase at a flow rate of 2mL-min. Wavelength was fixed at 225 nm. The retention time of cefixime and cloxacillin was found to be 5.657 and 6.200 min, respectively. The developed method is rapid and sensitive and it can be used for estimation of combination of these drugs in tablets.





Author: G. Rathinavel, P. B. Mukherjee, J. Valarmathy, L. Samueljoshua, M. Ganesh, T. Sivakumar, and T. Saravanan

Source: https://www.hindawi.com/



DOWNLOAD PDF




Related documents