Evaluation of the correlation of vasculogenic mimicry, ALDH1, KAI1 and microvessel density in the prediction of metastasis and prognosis in colorectal carcinomaReport as inadecuate




Evaluation of the correlation of vasculogenic mimicry, ALDH1, KAI1 and microvessel density in the prediction of metastasis and prognosis in colorectal carcinoma - Download this document for free, or read online. Document in PDF available to download.

BMC Surgery

, 17:47

Visceral and general surgery

Abstract

BackgroundMetastasis and recurrence are the most common reasons for treatment failure of colorectal carcinoma CRC. Vasculogenic mimicry VM, blood supply formation often seen in highly aggressive tumors, Aldehyde dehydrogenase 1 ALDH1, a biomarker of cancer stem cells, KAI1 a suppressor gene of tumor metastasis are all valuable factors for metastasis and prognosis in diverse human cancers. However, the correlation of VM, ALDH1, KAI1 and microvessel density MVD in CRC is unclear. In this study, we analyzed the correlations among VM, ALDH1, KAI1 and MVD, as well as their respective correlations with clinicopathological parameters and survival in CRC.

MethodsThe level of VM, ALDH1, KAI1 and MVD in 204 whole tissue samples of CRC were examined by immunhistochemistry. Clinical data was also collected.

ResultsLevels of VM, ALDH1 and MVD were significantly higher, and levels of KAI1 significantly lower, in CRC tissues than in normal colorectal tissues. Levels of VM, ALDH1 and MVD were positively associated with invasion of depth, lymph node metastasis LNM, distant metastasis and tumor-node-metastasis TNM stages, and negatively with patients’ overall survival OS. Levels of KAI1 was negatively correlated with invasion of depth, LNM, distant metastasis and TNM stages, and the KAI1 positive expression subgroup had significantly longer OS than did the KAI1- subgroup. In multivariate analysis, high levels of VM, ALDH1 and KAI1, as well as TNM stages were independently correlated with lower OS in patients with CRC.

ConclusionsVM, MVD and the expression of ALDH1 and KAI1 may represent promising metastatic and prognostic biomarkers, as well as potential therapeutic targets for CRC.

KeywordCRC VM ALDH1 KAI1 MVD Prognosis AbbreviationsAJCCAmerican Joint Committee on Cancer

ALDH1Aldehyde dehydrogenase 1

CIConfidence intervals

CRCColorectal carcinoma

CSCCancer stem cells

EMTEpithelial-mesenchymal transition

HRHazard ration

LNMLymph node metastasis

MVDMicrovessel density

OSOverall survival

PASPeriodic acid-Schiff

PBSPhosphate buffered saline

RTRoom temperature

TNMTumor node metastasis

VMVasculogenic mimicry

WHOWorld Health Organization





Author: Bo Zhu - Lei Zhou - Lan Yu - Shiwu Wu - Wenqing Song - Xiaomeng Gong - Danna Wang

Source: https://link.springer.com/







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