miR-16-1 Promotes the Aberrant α-Synuclein Accumulation in Parkinson Disease via Targeting Heat Shock Protein 70Report as inadecuate




miR-16-1 Promotes the Aberrant α-Synuclein Accumulation in Parkinson Disease via Targeting Heat Shock Protein 70 - Download this document for free, or read online. Document in PDF available to download.

The Scientific World JournalVolume 2014 2014, Article ID 938348, 8 pages

Research Article

Department of Neurology, General Hospital of Tianjin Medical University, No. 154, Anshan road, Heping District, Tianjin 300071, China

Department of Neurology, Affiliated Hospital of Inner Mongolia Medical University, No. 1 Tongdao North Street, Hohhot, Mongolia 010059, China

Received 25 April 2014; Accepted 22 May 2014; Published 23 June 2014

Academic Editor: Lin He

Copyright © 2014 Zhelin Zhang and Yan Cheng. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

There is striking evidence that heat shock protein 70 Hsp70 negatively regulates α-synuclein aggregation, which plays a significant role in the formation and progression of Parkinson disease PD. However, how the Hsp70 in neurons fails to prevent or even reverse α-synuclein aggregation and toxicity in PD still remains to be determined. In the present study, we constructed an α-synuclein-overexpressed human neuroblastoma cell line, SH-SY5Y-Syn, in which the blockage of Hsp70 promoted α-synuclein aggregation. And we also found that miR-16-1 downregulated Hsp70 and promoted α-synuclein aggregation in the SH-SY5Y-Syn cells. This study revealed a novel regulatory mechanism of Hsp70 expression, which might contribute to the PD development.





Author: Zhelin Zhang and Yan Cheng

Source: https://www.hindawi.com/



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