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Protein and Cell

, Volume 8, Issue 5, pp 315–327

First Online: 19 January 2017Received: 30 November 2016Accepted: 28 December 2016DOI: 10.1007-s13238-016-0368-0

Cite this article as: Sun, Y. & Ding, Q. Protein Cell 2017 8: 315. doi:10.1007-s13238-016-0368-0

Abstract

Precision medicine emerges as a new approach that takes into account individual variability. Successful realization of precision medicine requires disease models that are able to incorporate personalized disease information and recapitulate disease development processes at the molecular, cellular and organ levels. With recent development in stem cell field, a variety of tissue organoids can be derived from patient specific pluripotent stem cells and adult stem cells. In combination with the state-of-the-art genome editing tools, organoids can be further engineered to mimic disease-relevant genetic and epigenetic status of a patient. This has therefore enabled a rapid expansion of sophisticated in vitro disease models, offering a unique system for fundamental and biomedical research as well as the development of personalized medicine. Here we summarize some of the latest advances and future perspectives in engineering stem cell organoids for human disease modeling.

Keywordspluripotent-adult stem cell tissue organoid genome editing precision medicine 



Author: Yingmin Sun - Qiurong Ding

Source: https://link.springer.com/







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