Correlations between serum adipocytokine concentrations, disease stage, radiological status and total body fat content in the patients with primary knee osteoarthritisReport as inadecuate




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International Orthopaedics

, Volume 41, Issue 5, pp 983–989

First Online: 24 December 2016Received: 28 September 2016Accepted: 04 December 2016DOI: 10.1007-s00264-016-3370-5

Cite this article as: Richter, M., Trzeciak, T., Rybka, J.D. et al. International Orthopaedics SICOT 2017 41: 983. doi:10.1007-s00264-016-3370-5

Abstract

PurposeThe study was designed to investigate whether serum concentrations of leptin, resistin and adiponectin in obese and normal-weight patients with primary knee osteoarthritis OA correlate with clinical and radiological stages of the disease and percentage of total body fat.

MethodsSeventy-three patients with knee OA, divided into obese and normal-weight groups, were clinically evaluated according to the Knee Society Score KSS, and radiologically assessed using Kellgren and Lawrence scale. The percentage of total body fat and some anthropometric data were also given. Serum leptin, resistin and adiponectin concentrations were measured by Elisa and were correlated with the clinical, radiological and anthropometric parameters.

ResultsLeptin concentrations were significantly higher p = 0.001 in the obese patients and positively correlated R = 0.63 with radiologically assessed OA grade, but only in the normal-weight group. Resistin and adiponectin concentrations were identical in obese and normal-weight patients and negatively correlated R = −0.41 with the clinical status of obese patients. In both groups, percentage of total body fat positively correlated R = 0.29 and R = 0.53 for obese and normal-weight respectively with radiologically assessed OA grade. However, no correlations were found with clinical status of the patients.

ConclusionsIt was found that in the obese patients with knee OA, increased percentage of total body fat and elevated serum leptin concentration might favour the advancement of clinical but not radiologically assessed changes in the joint structures, while in normal-weight patients it correlates only with radiologically assessed changes but does not affect to an appreciable extent the clinical status of the patients.

KeywordsOsteoarthritis Obesity Leptin Resistin Adiponectin Magdalena Richter and Tomasz Trzeciak contributed equally to this work.





Author: Magdalena Richter - Tomasz Trzeciak - Jakub Dalibor Rybka - Wiktoria Suchorska - Ewelina Augustyniak - Michał Lach - Małg

Source: https://link.springer.com/







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