CD4 CD28null T Cells are related to previous cytomegalovirus infection but not to accelerated atherosclerosis in ANCA-associated vasculitisReport as inadecuate




CD4 CD28null T Cells are related to previous cytomegalovirus infection but not to accelerated atherosclerosis in ANCA-associated vasculitis - Download this document for free, or read online. Document in PDF available to download.

Rheumatology International

, Volume 37, Issue 5, pp 791–798

First Online: 13 January 2017Received: 21 July 2016Accepted: 21 December 2016DOI: 10.1007-s00296-016-3643-8

Cite this article as: Slot, M.C., Kroon, A.A., Damoiseaux, J.G.M.C. et al. Rheumatol Int 2017 37: 791. doi:10.1007-s00296-016-3643-8

Abstract

Previous studies have suggested an increased risk for cardiovascular events in antineutrophil cytoplasmic antibodies ANCA-associated vasculitis AAV. We analyzed the presence of atherosclerotic damage in patients with AAV in relation to the presence of CD4CD28 T cells and antibodies against cytomegalovirus CMV and human Heat-Shock Protein 60 hHSP60. In this cross-sectional study, patients with inactive AAV were compared with healthy controls HC. Carotid intima-media thickness IMT and aortic pulse-wave velocity PWV were measured. In addition, CD4CD28 T cells, anti-CMV, and anti-hHSP60 levels were determined. Forty patients with AAV were included. Patients’ spouses were recruited as HC N = 38. CD4CD28 T cells are present in patients with AAV in a higher percentage median 3.1, range 0.01–85 than in HC 0.28, 0–36, P < 0.0001. No significant difference in IMT mm between patients and controls was detected mean 0.77 ± standard deviation 0.15 and 0.73 ± 0.11, respectively, P = 0.20. PWV standardized for MAP was increased in AAV patients 9.80 ± 2.50 m-s, compared to 8.72 ± 1.68 in HC, P = 0.04. There was a strong association between a previous CMV infection and the presence and percentage of CD4CD28 T cells 0.33 vs 13.8, P < 0.001. There was no relationship between CD4CD28 T cells and-or a previous CMV infection and IMT or PWV. There was no relation between anti-hHSP60 and CD4CD28 T cells. Increased PWV values suggest atherosclerotic damage in patients with AAV. Plaque size, as determined by IMT, did not differ. CD4CD28 T cells are increased in AAV and related to the previous CMV infection.

KeywordsANCA Vasculitis Atherosclerosis CD4CD28 T cells Cytomegalovirus Intima-media thickness 



Author: Marjan C. Slot - Abraham A. Kroon - Jan G. M. C. Damoiseaux - Ruud Theunissen - Alfons J. H. M. Houben - Peter W. d

Source: https://link.springer.com/







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