Variations in Adipokine Genes AdipoQ, Lep, and LepR are Associated with Risk for Obesity-Related Metabolic Disease: The Modulatory Role of Gene-Nutrient InteractionsReport as inadecuate




Variations in Adipokine Genes AdipoQ, Lep, and LepR are Associated with Risk for Obesity-Related Metabolic Disease: The Modulatory Role of Gene-Nutrient Interactions - Download this document for free, or read online. Document in PDF available to download.

Journal of ObesityVolume 2011 2011, Article ID 168659, 17 pages

Review Article

Department of Physiology, University of Manitoba and Canadian Centre for Agri-Food Research in Health and Medicine, St. Boniface Hospital Research Centre, 351 Tache Ave, Winnipeg, Manitoba, R2H 2A6, Canada

Departments of Human Nutritional Sciences and Physiology, University of Manitoba, 351 Tache Ave, Winnipeg, Manitoba, R2H 2A6, Canada

Departments of Physiology and Human Nutritional Sciences, University of Manitoba and Canadian Centre for Agri-Food Research in Health and Medicine, St. Boniface Hospital Research Centre, 351 Tache Ave, Winnipeg, Manitoba, R2H 2A6, Canada

Received 9 January 2011; Accepted 10 March 2011

Academic Editor: P. Trayhurn

Copyright © 2011 Jennifer Emily Enns et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Obesity rates are rapidly increasing worldwide and facilitate the development of many related disease states, such as cardiovascular disease, the metabolic syndrome, type 2 diabetes mellitus, and various types of cancer. Variation in metabolically important genes can have a great impact on a population-s susceptibility to becoming obese and-or developing related complications. The adipokines adiponectin and leptin, as well as the leptin receptor, are major players in the regulation of body energy homeostasis and fat storage. This paper summarizes the findings of single nucleotide polymorphisms in these three genes and their effect on obesity and metabolic disease risk. Additionally, studies of gene-nutrient interactions involving adiponectin, leptin, and the leptin receptor are highlighted to emphasize the critical role of diet in susceptible populations.





Author: Jennifer Emily Enns, Carla G. Taylor, and Peter Zahradka

Source: https://www.hindawi.com/



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