Advanced myocardial tissue characterisation by a multi-component CMR protocol in patients with rheumatoid arthritisReport as inadecuate




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European Radiology

pp 1–11

First Online: 12 May 2017Received: 04 November 2016Revised: 21 March 2017Accepted: 03 April 2017DOI: 10.1007-s00330-017-4838-4

Cite this article as: Greulich, S., Mayr, A., Kitterer, D. et al. Eur Radiol 2017. doi:10.1007-s00330-017-4838-4

Abstract

ObjectivesRheumatoid arthritis RA patients are at increased risk of suffering from adverse cardiovascular events. Cardiovascular magnetic resonance CMR mapping techniques might be appropriate tools to complement late gadolinium enhancement LGE for the assessment of myocardial involvement. This study aimed to perform advanced myocardial tissue characterisation in RA patients by a multicomponent CMR protocol.

Methods22 RA patients were prospectively enrolled and underwent CMR, including LGE and T1-T2 mapping sequences; 20 volunteers served as controls.

ResultsMean LV-EF was 66%; prevalence of LGE was 18%. RA patients had increased native T1 985 vs. 959 ms, p = 0.03, expanded extracellular volume ECV 27 vs. 25%, p = 0.02 and higher T2 values 52 vs. 49 ms, p < 0.001 compared to controls irrespective of the presence of LGE. T2 mapping showed the highest prevalence of values beyond the 95% percentile of controls.

ConclusionRA patients demonstrated higher T1, ECV and T2 values compared to controls, with most significant differences for T2. Since these results seem to be independent of the presence of LGE, advanced myocardial tissue characterisation including CMR mapping techniques in addition to LGE-CMR might be useful in the evaluation of myocardial involvement in RA patients.

Key points• RA patients had higher T1, ECV and T2 values compared to controls.

• Most significant differences were observed for T2.

• Our results seem to be independent of the presence of LGE.

• Mapping might be useful in the evaluation of myocardial involvement in RA.

KeywordsRheumatoid arthritis Myocardial involvement Cardiovascular magnetic resonance Late gadolinium enhancement Mapping AbbreviationsCMRcardiovascular magnetic resonance

CVDcardiovascular disease

ECGelectrocardiogram

ECVextracellular volume

EMBendomyocardial biopsy

IQRinterquartile range

IVSinterventricular septum

LAleft atrium

LGElate gadolinium enhancement

LVleft ventricle

LV-EDVleft ventricular end-diastolic volume

LV-EFleft ventricular ejection fraction

LV-ESVleft ventricular end-systolic volume

MOLLImodified look-locker inversion recovery sequence

RArheumatoid arthritis

SCDsudden cardiac death

SSFPsteady-state free-precession





Author: Simon Greulich - Agnes Mayr - Daniel Kitterer - Joerg Latus - Joerg Henes - Francesco Vecchio - Philipp Kaesemann - Alexand

Source: https://link.springer.com/







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