Spindle Activity Orchestrates Plasticity during Development and SleepReport as inadecuate




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Neural Plasticity - Volume 2016 2016, Article ID 5787423, 14 pages -

Review ArticleDevelopmental Neurophysiology, Institute of Neuroanatomy, University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany

Received 29 January 2016; Accepted 13 April 2016

Academic Editor: Adrien Peyrache

Copyright © 2016 Christoph Lindemann et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Spindle oscillations have been described during early brain development and in the adult brain. Besides similarities in temporal patterns and involved brain areas, neonatal spindle bursts NSBs and adult sleep spindles ASSs show differences in their occurrence, spatial distribution, and underlying mechanisms. While NSBs have been proposed to coordinate the refinement of the maturating neuronal network, ASSs are associated with the implementation of acquired information within existing networks. Along with these functional differences, separate synaptic plasticity mechanisms seem to be recruited. Here, we review the generation of spindle oscillations in the developing and adult brain and discuss possible implications of their differences for synaptic plasticity. The first part of the review is dedicated to the generation and function of ASSs with a particular focus on their role in healthy and impaired neuronal networks. The second part overviews the present knowledge of spindle activity during development and the ability of NSBs to organize immature circuits. Studies linking abnormal maturation of brain wiring with neurological and neuropsychiatric disorders highlight the importance to better elucidate neonatal plasticity rules in future research.





Author: Christoph Lindemann, Joachim Ahlbeck, Sebastian H. Bitzenhofer, and Ileana L. Hanganu-Opatz

Source: https://www.hindawi.com/



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