Alpha-Beta T-Cell Depleted Grafts as an Immunological Booster to Treat Graft Failure after Hematopoietic Stem Cell Transplantation with HLA-Matched Related and Unrelated DonorsReport as inadecuate




Alpha-Beta T-Cell Depleted Grafts as an Immunological Booster to Treat Graft Failure after Hematopoietic Stem Cell Transplantation with HLA-Matched Related and Unrelated Donors - Download this document for free, or read online. Document in PDF available to download.

Journal of Immunology Research - Volume 2014 2014, Article ID 578741, 14 pages -

Research Article

Department of Oncology and Pathology, Karolinska Institutet, 141 86 Stockholm, Sweden

Center for Allogeneic Stem Cell Transplantation, Karolinska University Hospital, 141 86 Stockholm, Sweden

Department of Clinical Immunology and Transfusion Medicine, Karolinska University Hospital, 141 86 Stockholm, Sweden

Received 5 May 2014; Revised 4 September 2014; Accepted 4 September 2014; Published 13 October 2014

Academic Editor: David E. Gilham

Copyright © 2014 E. Rådestad et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Allogeneic hematopoietic stem cell transplantation is associated with several complications and risk factors, for example, graft versus host disease GVHD, viral infections, relapse, and graft rejection. While high levels of CD3+ cells in grafts can contribute to GVHD, they also promote the graft versus leukemia GVL effect. Infusions of extra lymphocytes from the original stem cell donor can be used as a treatment after transplantation for relapse or poor immune reconstitution but also they increase the risk for GVHD. In peripheral blood, 95% of T-cells express the T-cell receptor and the remaining T-cells express the T-cell receptor. As T-cells are the primary mediators of GVHD, depleting them from the graft should reduce this risk. In this pilot study, five patients transplanted with HLA-matched related and unrelated donors were treated with T-cell depleted stem cell boosts. The majority of T-cells in the grafts expressed and-or . Most patients receiving -depleted stem cell boosts increased their levels of white blood cells, platelets, and-or granulocytes 30 days after infusion. No signs of GVHD or other side effects were detected. A larger pool of patients with longer follow-up time is needed to confirm the data in this study.





Author: E. Rådestad, H. Wikell, M. Engström, E. Watz, B. Sundberg, S. Thunberg, M. Uzunel, J. Mattsson, and M. Uhlin

Source: https://www.hindawi.com/



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