Brain White Matter Impairment in Patients with Spinal Cord InjuryReport as inadecuate




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Neural Plasticity - Volume 2017 2017, Article ID 4671607, 8 pages - https:-doi.org-10.1155-2017-4671607

Research Article

Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing, China

Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, Beijing, China

Department of Radiology, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing, China

Department of Radiology, Tianjin Medical University General Hospital, Tianjin, China

Correspondence should be addressed to Nan Chen

Received 1 August 2016; Accepted 12 January 2017; Published 1 February 2017

Academic Editor: Nam-Jong Paik

Copyright © 2017 Weimin Zheng et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

It remains unknown whether spinal cord injury SCI could indirectly impair or reshape the white matter WM of human brain and whether these changes are correlated with injury severity, duration, or clinical performance. We choose tract-based spatial statistics TBSS to investigate the possible changes in whole-brain white matter integrity and their associations with clinical variables in fifteen patients with SCI. Compared with the healthy controls, the patients exhibited significant decreases in WM fractional anisotropy FA in the left angular gyrus AG, right cerebellum CB, left precentral gyrus PreCG, left lateral occipital region LOC, left superior longitudinal fasciculus SLF, left supramarginal gyrus SMG, and left postcentral gyrus PostCG , TFCE corrected. No significant differences were found in all diffusion indices between the complete and incomplete SCI. However, significantly negative correlation was shown between the increased radial diffusivity RD of left AG and total motor scores uncorrected . Our findings provide evidence that SCI can cause not only direct degeneration but also transneuronal degeneration of brain WM, and these changes may be irrespective of the injury severity. The affection of left AG on rehabilitation therapies need to be further researched in the future.





Author: Weimin Zheng, Qian Chen, Xin Chen, Lu Wan, Wen Qin, Zhigang Qi, Nan Chen, and Kuncheng Li

Source: https://www.hindawi.com/



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