Clinical and Pathological Implications of Concurrent Autoimmune Thyroid Disorders and Papillary Thyroid CancerReport as inadecuate




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Journal of Thyroid ResearchVolume 2011 2011, Article ID 387062, 13 pages

Review Article

Laboratory of Cancer Molecular Genetics, Faculty of Medical Sciences, University of Campinas FCM-Unicamp, 126 Tessalia Vieira de Camargo St., Cidade Universitária, Barão Geraldo, Campinas, 13083-970 São Paulo, SP, Brazil

Laboratory of Molecular Pathology, Ciped, Faculty of Medical Sciences, University of Campinas Unicamp, 126 Tessalia Vieira de Camargo St., Cidade Universitária, Barão Geraldo, Campinas, 13083-970 , São Paulo, SP, Brazil

Received 29 August 2010; Revised 26 October 2010; Accepted 16 December 2010

Academic Editor: Gary L. Francis

Copyright © 2011 L. L. Cunha et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Cooccurrences of chronic lymphocytic thyroiditis CLT and thyroid cancer DTC have been repeatedly reported. Both CLT and DTC, mainly papillary thyroid carcinoma PTC, share some epidemiological and molecular features. In fact, thyroid lymphocytic inflammatory reaction has been observed in association with PTC at variable frequency, although the precise relationship between the two diseases is still debated. It also remains a matter of debate whether the association with a CLT or even an autoimmune disorder could influence the prognosis of PTC. A better understanding about clinical implications of autoimmunity in concurrent thyroid cancer could raise new insights of thyroid cancer immunotherapy. In addition, elucidating the molecular mechanisms involved in autoimmune disease and concurrent cancer allowed us to identify new therapeutic strategies against thyroid cancer. The objective of this article was to review recent literature on the association of these disorders and its potential significance.





Author: L. L. Cunha, R. C. Ferreira, M. A. Marcello, J. Vassallo, and L. S. Ward

Source: https://www.hindawi.com/



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