Autoantibodies to Tailor-Made Panels of Tumor-Associated Antigens in Breast CarcinomaReport as inadecuate




Autoantibodies to Tailor-Made Panels of Tumor-Associated Antigens in Breast Carcinoma - Download this document for free, or read online. Document in PDF available to download.

Journal of OncologyVolume 2011 2011, Article ID 982425, 7 pages

Review Article

Department of Obstetrics and Gynecology, Sapir Medical Center, Sackler School of Medicine, University of Tel-Aviv, Kfar-Saba 44281, Israel

Unit of Gynecologic Oncology, Department of Obstetrics and Gynecology, Soroka Medical Center and Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 84101, Israel

Received 31 October 2010; Accepted 14 January 2011

Academic Editor: Aysegula A. Sahin

Copyright © 2011 Ettie Piura and Benjamin Piura. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Autoantibodies AAbs to tumor-associated antigens TAAs have been identified in the sera of cancer patients. In a previous review published in this journal, we have focused on recent knowledge related to circulating AAbs to individual TAAs in breast carcinoma. This review will focus on recent knowledge related to AAb assays to tailor-made panels of TAAs in breast carcinoma. So far, AAb assays to the following tailor-made panels of TAAs have been assessed in breast carcinoma: 1 p53, c-myc, HER2, NY-ESO-1, BRCA2, and MUC1, 2 IMP1, p62, Koc, p53, c-MYC, cyclin B1, and survivin, 3 PPIA, PRDX2, FKBP52, HSP-60, and MUC1, 4 MUC1, HER2, p53, and IGFBP2, 5 p53, HER2, IGFBP-2, and TOPO2α, 6 survivin and livin, 7 ASB-9, SERAC1, and RELT, and 8 p16, p53, and c-myc. Assessment of serum AAbs to a tailor-made panel of TAAs provides better sensitivity to diagnosis of breast carcinoma than measuring serum AAbs to a single TAA. Nevertheless, measurement of serum AAbs to a panel of TAAs for screening and early diagnosis of breast carcinoma is still investigational and should be carried out along with traditional diagnostic studies.





Author: Ettie Piura and Benjamin Piura

Source: https://www.hindawi.com/



DOWNLOAD PDF




Related documents