Synthesis, Characterization, Mössbauer Parameters, and Antitumor Activity of FeIII Curcumin ComplexReport as inadecuate




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Bioinorganic Chemistry and ApplicationsVolume 2013 2013, Article ID 982423, 5 pages

Research ArticleChemistry Department, King Saud University, Riyadh 11451, Saudi Arabia

Received 13 December 2012; Revised 4 March 2013; Accepted 4 March 2013

Academic Editor: Giovanni Natile

Copyright © 2013 Mutasim Ibrahim Khalil et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Curcumin-FeIII complex was prepared from FeNO33·9H2O precursor and curcumin by refluxing a slightly basic methanolic solution of their mixture with the objective of investigating its cytotoxicity. The enol form of curcumin ligand was established by FTIR, UV-Vis,

H NMR, and

C NMR spectroscopy. The as-prepared product was characterized by elemental analysis, FTIR, UV, and Mössbauer spectroscopic techniques. An octahedral high-spin FeIII complex was obtained, δ, 0.37 mms

; Q.S., 0.79 mms

; no magnetic relaxation was observed at liquid N2 temperature, neither reduction of FeIII. The tested cytotoxicity of the as-prepared complex on four cancer cell lines indicated inhibition of the curcumin activity upon complexing with iron.





Author: Mutasim Ibrahim Khalil, Aisha Mohamed Al-Zahem, and Maha Hamad Al-Qunaibit

Source: https://www.hindawi.com/



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