Total synthesis of malagashanine: a chloroquine potentiating indole alkaloid with unusual stereochemistryReport as inadecuate




Total synthesis of malagashanine: a chloroquine potentiating indole alkaloid with unusual stereochemistry - Download this document for free, or read online. Document in PDF available to download.

Journal Title:

Chemical Science

Volume:

Volume 8, Number 1

Publisher:

Royal Society of Chemistry | 2016-09-19, Pages 697-700

Type of Work:

Article | Final Publisher PDF

Abstract: The first total synthesis of malagashanine, a chloroquine potentiating indole alkaloid, is presented. A highly stereoselective cascade annulation reaction was developed to generate the tetracyclic core of the Malagasy alkaloids. This chemistry is likely to be broadly applicable to the synthesis of other members of this stereochemically unique family of natural products.

Subject: Chemistry, General - Research Funding: This research was supported by the NSF CHE-1362502.





Author: A Kong, DE Mancheno, N Boudet, R Delgado, Eric S. Andreansky, Simon Blakey,

Source: https://open.library.emory.edu/



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