High expression of myoferlin is associated with poor outcome in oropharyngeal squamous cell carcinoma patients and is inversely associated with HPV-statusReport as inadecuate




High expression of myoferlin is associated with poor outcome in oropharyngeal squamous cell carcinoma patients and is inversely associated with HPV-status - Download this document for free, or read online. Document in PDF available to download.

Journal Title:

Oncotarget

Volume:

Volume 7, Number 14

Publisher:

Impact Journals | 2016-04-05, Pages 18665-18677

Type of Work:

Article | Final Publisher PDF

Abstract: Myoferlin MYOF is a member of ferlin family of membrane proteins that was originally discovered as a muscle specific protein. Recent studies have shown that myoferlin is also expressed in other cell types including endothelial cells and cancer cells. However, very little is known about the expression and biological role of myoferlin in head and neck cancer. In this study, we examined expression profile of myoferlin in oropharyngeal squamous cell carcinoma OPSCC and assessed its correlation with disease progression and patient outcome. In univariate analyses, nuclear MYOF was associated with poor overall survival p < 0.001 and these patients had 5.5 times increased hazard of death 95% Cl 3.4-8.8. Nuclear myoferlin expression was also directly associated with tumor recurrence p < 0.001, perineural invasion p=0.008, extracapsular spread p=0.009, higher T-stage p=0.0015 and distant metastasis p < 0.001. In addition, nuclear MYOF expression was directly associated with IL-6 p < 0.001 and inversely with HPV status p=0.0014. In a subgroup survival analysis, MYOF nuclear+-IL-6+ group had worst survival 84.6% mortality, whereas MYOF nuclear-IL-6- had the best survival. Similarly, patients with HPV-negative-MYOFpositive tumors had worse survival compared to HPV-positive-MYOF-negative. Taken together, our results demonstrate for the first time that nuclear myoferlin expression independently predicts poor clinical outcome in OPSCC patients.

Subjects: Health Sciences, Oncology - Biology, Biostatistics - Health Sciences, Pathology - Research Funding: NIH-NCI-CA178649 P. Kumar and The Ohio State University Comprehensive Cancer Center.

Keywords: Science and Technology - Life Sciences and Biomedicine - Oncology - Cell Biology - myoferlin - OPSCC - HPV - IL-6 - nanog - GIRDLE MUSCULAR-DYSTROPHY - QUALITY-OF-LIFE - HUMAN-PAPILLOMAVIRUS - NECK-CANCER - GENE-EXPRESSION - BREAST-CANCER - PHOSPHOLIPID-BINDING - FER-1-LIKE PROTEIN - MYOBLAST FUSION - HEAD -



Author: Bhavna Kumar, Nicole V. Brown, Benjamin J. Swanson, Alessandra Schmitt, Matthew Old, Enver Ozer, Amit Agrawal, David E. Schuller,

Source: https://open.library.emory.edu/



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