Maternal antecedents of adiposity and studying the transgenerational role of hyperglycemia and insulin MAASTHI: a prospective cohort studyReport as inadecuate




Maternal antecedents of adiposity and studying the transgenerational role of hyperglycemia and insulin MAASTHI: a prospective cohort study - Download this document for free, or read online. Document in PDF available to download.

Journal Title:

BMC Pregnancy and Childbirth

Volume:

Volume 16, Number 1

Publisher:

BioMed Central | 2016-12

Type of Work:

Article | Final Publisher PDF

Abstract: Background: India is experiencing an epidemic of obesity-hyperglycaemia, which coincides with child bearing age for women. The epidemic can be sustained and augmented through transgenerational transmission of adiposity and glucose intolerance in women. This presents an opportunity for exploring a clear strategy for the control of this epidemic in India. We conducted a study between November 2013 and May 2015 to inform the design of a large pregnancy cohort study. Based on the findings of this pilot, we developed the protocol for the proposed birth cohort of 5000 women, the recruitment for which will start in April 2016. The protocol of the study documents the processes which aim at advancing the available knowledge, linking several steps in the evolution of obesity led hyperglycemia.Methods: Maternal Antecedents of Adiposity and Studying the Transgenerational role of Hyperglycemia and Insulin MAASTHI is a cohort study in the public health facilities in Bangalore, India. The objective of MAASTHI is to prospectively assess the effects of glucose levels in pregnancy on the risk of adverse infant outcomes, especially in predicting the possible risk markers of later chronic diseases. The primary objective of the proposed study is to investigate the effect of glucose levels in pregnancy on skinfold thickness adiposity in infancy as a marker of future obesity and diabetes in offspring. The secondary objective is to assess the association between psychosocial environment of mothers and adverse neonatal outcomes including adiposity. The study aims to recruit 5000 pregnant women and follow them and their offspring for a period of 4 years. The institutional review board at The Indian Institute of Public Health IIPH-H, Bangalore, Public Health Foundation of India has approved the protocol. All participants are required to provide written informed consent.Discussion: The findings from this study may help to address important questions on screening and management of high blood sugar in pregnancy. It may provide critical information on the specific determinants driving the underweight-obesity-T2DM epidemic in India. The study can inform the policy regarding the potential impact of screening and management protocols in public healthcare facilities. The public health implications include prioritising issues of maternal glycemic control and weight management and better understanding of the lifecourse determinants in the development of T2DM.

Subjects: Health Sciences, Epidemiology - Health Sciences, Obstetrics and Gynecology - Health Sciences, Public Health - Research Funding: The MAASTHI cohort is funded by an Intermediate Fellowship by the Wellcome Trust DBT India Alliance Clinical and Public Health Research Fellowships.

Keywords: Gestational diabetes - Hyperglycemia - Obesity - Birth cohort - Protocol - Lifecourse epidemiology -



Author: Giridhara R. Babu, GVS Murthy, R. Deepa, Yamuna, Prafulla, H. Kiran Kumar, Maithili Karthik, Keerti Deshpande, Sara E. Benjamin N

Source: https://open.library.emory.edu/



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