The Role of Adipose-Derived Stem Cells in Breast Cancer Progression and MetastasisReport as inadecuate




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Stem Cells International - Volume 2015 2015, Article ID 120949, 17 pages -

Review Article

Department of Plastic Surgery and Hand Surgery, University Hospital Zurich, 8006 Zurich, Switzerland

Adipose Stem Cell Center, Department of Plastic Surgery, University of Pittsburgh, Pittsburgh, PA 15261, USA

McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA

Department of Surgery, Shiga Medical Center for Adults, Shiga 524-8525, Japan

Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15261, USA

Received 31 October 2014; Accepted 26 December 2014

Academic Editor: Oswaldo Keith Okamoto

Copyright © 2015 Riccardo Schweizer et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Conventional breast cancer extirpation involves resection of parts of or the whole gland, resulting in asymmetry and disfiguration. Given the unsatisfactory aesthetic outcomes, patients often desire postmastectomy reconstructive procedures. Autologous fat grafting has been proposed for reconstructive purposes for decades to restore form and anatomy after mastectomy. Fat has the inherent advantage of being autologous tissue and the most natural-appearing filler, but given its inconsistent engraftment and retention rates, it lacks reliability. Implementation of autologous fat grafts with cellular adjuncts, such as multipotent adipose-derived stem cells ADSCs, has shown promising results. However, it is pertinent and critical to question whether these cells could promote any residual tumor cells to proliferate, differentiate, or metastasize or even induce de novo carcinogenesis. Thus far, preclinical and clinical study findings are discordant. A trend towards potential promotion of both breast cancer growth and invasion by ADSCs found in basic science studies was indeed not confirmed in clinical trials. Whether experimental findings eventually correlate with or will be predictive of clinical outcomes remains unclear. Herein, we aimed to concisely review current experimental findings on the interaction of mesenchymal stem cells and breast cancer, mainly focusing on ADSCs as a promising tool for regenerative medicine, and discuss the implications in clinical translation.





Author: Riccardo Schweizer, Wakako Tsuji, Vijay S. Gorantla, Kacey G. Marra, J. Peter Rubin, and Jan A. Plock

Source: https://www.hindawi.com/



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