Acupoint-Specific, Frequency-Dependent, and Improved Insulin Sensitivity Hypoglycemic Effect of Electroacupuncture Applied to Drug-Combined Therapy Studied by a Randomized Control Clinical TrialReport as inadecuate




Acupoint-Specific, Frequency-Dependent, and Improved Insulin Sensitivity Hypoglycemic Effect of Electroacupuncture Applied to Drug-Combined Therapy Studied by a Randomized Control Clinical Trial - Download this document for free, or read online. Document in PDF available to download.

Evidence-Based Complementary and Alternative Medicine - Volume 2014 2014, Article ID 371475, 9 pages -

Review Article

Department of Internal Medicine and Emergency Medicine, Division of Endocrinology and Metabolism, Tungs’ Taichung Metro Harbor Hospital, Taichung County 43503, Taiwan

Department of Occupational Safety and Health, Jen-Teh Junior College of Medicine, Nursing and Management, Houlong, Miaoli County 35664, Taiwan

Department of Orthopedics, Taichung Veterans General Hospital, Taichung 40705, Taiwan

Institute of Molecular Medicine, College of Life Science, National Tsing Hua University, Hsinchu 30013, Taiwan

Department of Acupuncture, China Medical University Hospital, Taichung 40402, Taiwan

Department of Medicinal Botanicals and Health Application, Da-Yeh University, No. 168, University Road, Dacun, Changhua County 51591, Taiwan

School of Chinese Medicine, China Medical University, Taichung 40402, Taiwan

Received 22 March 2014; Revised 28 April 2014; Accepted 6 May 2014; Published 16 June 2014

Academic Editor: Xin-Yan Gao

Copyright © 2014 Rong-Tsung Lin et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The application of electroacupuncture EA to specific acupoints can induce a hypoglycemic effect in streptozotocin-induced rats, normal rats, and rats with steroid-induced insulin resistance. EA combined with the oral insulin sensitizer rosiglitazone improved insulin sensitivity in rats and humans with type II diabetes mellitus DM. There are different hypoglycemic mechanisms between Zhongwan and Zusanli acupoints by EA stimulation. On low-frequency 2 Hz stimulation at bilateral Zusanli acupoints, serotonin was involved in the hypoglycemic effect in normal rats. Moreover, after 15 Hz EA stimulation at the bilateral Zusanli acupoints, although enhanced insulin activity mainly acts on the insulin-sensitive target organs, the muscles must be considered. In addition, 15 Hz EA stimulation at the bilateral Zusanli acupoints has the combined effect of enhancing cholinergic nerve activity and increasing nitric oxide synthase NOS activity to enhance insulin activity. Despite the well-documented effect of pain control by EA in many systemic diseases, there are few high-quality long-term clinical trials on the hypoglycemic effect of EA in DM. Combination treatment with EA and other medications seems to be an alternative treatment to achieve better therapeutic goals that merit future investigation.





Author: Rong-Tsung Lin, Chung-Yuh Tzeng, Yu-Chen Lee, Ying-I Chen, Tai-Hao Hsu, Jaung-Geng Lin, and Shih-Liang Chang

Source: https://www.hindawi.com/



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