Proteases Revisited: Roles and Therapeutic Implications in FibrosisReport as inadecuate

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Mediators of Inflammation - Volume 2017 2017, Article ID 2570154, 14 pages -

Review ArticleInstitute of Medical Biology, Polish Academy of Sciences, Lodz, Poland

Correspondence should be addressed to Joanna Boncela

Received 20 January 2017; Accepted 13 April 2017; Published 31 May 2017

Academic Editor: Christine-Maria Horejs

Copyright © 2017 Jakub Kryczka and Joanna Boncela. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Proteases target many substrates, triggering changes in distinct biological processes correlated with cell migration, EMT-EndMT and fibrosis. Extracellular protease activity, demonstrated by secreted and membrane-bound protease forms, leads to ECM degradation, activation of other proteases i.e., proteolysis of nonactive zymogens, decomposition of cell-cell junctions, release of sequestered growth factors TGF-β and VEGF, activation of signal proteins and receptors, degradation of inflammatory inhibitors or inflammation-related proteins, and changes in cell mechanosensing and motility. Intracellular proteases, mainly caspases and cathepsins, modulate lysosome activity and signal transduction pathways. Herein, we discuss the current knowledge on the multidimensional impact of proteases on the development of fibrosis.

Author: Jakub Kryczka and Joanna Boncela



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