IL-33 and ST2 levels in chronic kidney disease: Associations with inflammation, vascular abnormalities, cardiovascular events, and survivalReport as inadecuate




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Objective

Increased inflammation, associated with the increase in chronic kidney disease CKD stage, has a very important influence in vascular injury and cardiovascular diseases. In this study, we aimed to investigate the levels of IL-33 and ST2 in the different stages of CKD and to determine their effect on vascular damage and cardiovascular events CVE.

Methods

This was an observational cohort study in which serum IL-33 and ST2 were obtained from 238 CKD stages 1–5 patients. We examined the changes in IL-33-ST2 levels in CKD patients, as well as the association with a surrogate of endothelial dysfunction. Fatal and non-fatal CVE were recorded for a mean of 24 months. We also performed a COX regression analysis to determine the association of IL-33-ST2 levels with CVE and survival.

Results

IL-33 and ST2 levels were significantly increased and estimated glomerular filtration rates eGFR were decreased. Flow-mediated dilatation FMD was significantly decreased from stage 1 to stage 5 CKD. IL-33 and ST2 levels were associated with FMD, and ST2 was a predictor. Multivariate Cox analysis showed that the presence of diabetes mellitus, smoking, and proteinuria and haemoglobin, Hs-CRP, IL-33, and ST2 were associated with the risk of CVE. Kaplan-Meier survival curves showed that patients with IL-33 and ST2 levels below the median value IL-33 = 132.6 ng-L, ST2 = 382.9 pg-mL had a higher cumulative survival compared with patients who had IL-33 and ST2 levels above the median value log-rank test, p = 0.000.

Conclusion

This is the first study that demonstrates that serum IL-33 and ST2 are associated with vascular injury, cardiovascular events, and survival in CKD patients.



Author: Ozkan Gungor , Hilmi Umut Unal, Aydin Guclu, Mustafa Gezer, Tayfun Eyileten, Fatma Betül Guzel, Orcun Altunoren, Ertugrul Erken,

Source: http://plos.srce.hr/



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