Interim estimates of the effectiveness of the influenza vaccine against AH3N2 influenza in adults in South Korea, 2016–2017 seasonReport as inadecuate




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In the 2016–2017 season, the AH3N2 influenza epidemic presented an unusual early peak pattern compared with past seasons in South Korea. The interim vaccine effectiveness VE of influenza vaccination in preventing laboratory-confirmed influenza was estimated using test-negative design through the tertiary hospital-based influenza surveillance system in South Korea. From 1 September, 2016 to 7 January, 2017, adjusted VE of influenza vaccination in preventing laboratory-confirmed AH3N2 was -52.1% 95% confidence interval CI -147.2 to 6.4; -70.0% 95% CI -212.0 to 7.4 in 19–64 years and 4.3% 95% CI -137.8 to 61.5 in the elderly. Circulating AH3N2 viruses belonged to the three phylogenetic subclades of 3C.2a, differently to A-Hong Kong-4801-2014, the current vaccine strain. Amino acid substitutions in hemagglutinin of circulating viruses seem to contribute to low VE. In conclusion, interim VE analysis presented that the protection of laboratory-confirmed influenza by seasonal influenza vaccination did not show the statistical significance in South Korea in the 2016–2017 influenza season.



Author: Ji Yun Noh , Sooyeon Lim , Joon Young Song, Won Suk Choi, Hye Won Jeong, Jung Yeon Heo, Jacob Lee, Yu Bin Seo, Jin-Soo Lee, Seong

Source: http://plos.srce.hr/



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