Is aspirin associated with diabetic retinopathy The Singapore Epidemiology of Eye Disease SEED studyReport as inadecuate




Is aspirin associated with diabetic retinopathy The Singapore Epidemiology of Eye Disease SEED study - Download this document for free, or read online. Document in PDF available to download.

Background-Aims

To determine the association between aspirin use and diabetic retinopathy DR among persons with diabetes, in a population-based, cross-sectional study.

Methods

Subjects with diabetes aged >40 years from the Singapore Epidemiology of Eye Diseases Study were enrolled in this study. Retinal photographs were graded for DR according to the modified Airlie House classification system. Vision threatening diabetic retinopathy VTDR was defined as the presence of severe non-proliferative DR, or proliferative DR, or clinically significant macular oedema. The association between aspirin use and the presence of DR or VTDR was assessed using multivariable logistic regression models including age, gender, ethnicity, socioeconomic status, HbA1c, systolic blood pressure, anti-hypertension medicine, total cholesterol, anti-cholesterol medicine, BMI, current smoking status, diabetes duration, history of cardiovascular disease CVD and chronic kidney disease CKD



Results

A total of 2,061 participants with diabetes and complete record of relevant systemic and DR data were included. Of these, 711 34.5% had any stage of DR, and among these 177 8.6% had VTDR. After adjusting for co-variables listed, the association between aspirin use and VTDR was significant OR = 1.69, P = 0.019, while the association between aspirin use and any DR was borderline OR = 1.31, P = 0.063. Aspirin use was not associated with either DR or VTDR after additional adjustment of CVD and CKD. Further stratification by history of CVD or CKD showed no association between aspirin use and DR-VTDR in either subgroup.

Conclusion

Aspirin use was not significantly associated with DR but might be an indicator of diabetic complications CVD, CKD that were co-present with more severe DR type. Future longitudinal studies are warranted to confirm our findings.



Author: Yuan Shi, Yih-Chung Tham, Ning Cheung, Jacqueline Chua, Gavin Tan, Paul Mitchell, Jie Jin Wang, Yin Bun Cheung, Ching-Yu Cheng, T

Source: http://plos.srce.hr/



DOWNLOAD PDF




Related documents