Statin adherence and the risk of Parkinsons disease: A population-based cohort studyReport as inadecuate




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Background

While experimental data provided some compelling evidence on the benefits of statins on dopaminergic neurons, observational studies reported conflicting results regarding the potential of statins to effect the risk of Parkinson’s disease PD.

Objectives

To evaluate the association between changes in statin adherence over time and PD risk.

Methods

A population-based cohort of new statin users ages 40-79, years 1999-2012 was derived from a large Israeli healthcare services organization. Data included history of statin purchases and low density lipoprotein cholesterol LDL-C levels. Personal statin adherence was measured annually by the proportion of days covered PDC. PD was detected employing a drug-tracer approach. Stratified by sex, LDL-C levels at baseline and age Cox proportional hazards models with time-dependent covariates were used to compute adjusted Hazard Ratio HR with 95%CI.

Results

The cohort included 232,877 individuals, 49.3% men. Mean age at first statin purchase was 56.5 ±9.8 years for men and 58.7 ±9.2 years for women. PDC distribution for the whole follow up period differed between men and women: medians 58.3% and 54.1% respectively. During a mean follow up of 7.6 ±3.4 years, 2,550 1.1% PD cases were identified. In a 1-year lagged analysis, we found no association between annual statin adherence and PD risk in all age-groups regardless of statin type and potency. Age-pooled HR 95%CI for men and women with LDL-C levels at baseline ≤160mg-dL were: 0.99 0.99-1.01, 1.01 1.00-1.02; and for men and women with LDL-C >160mg-dL levels: 0.99 0.98-1.01, 0.97 0.98-1.01.

Conclusions

Our findings suggest that statin adherence over time does not affect PD risk. Future studies should use large-scale cohorts and refining assessments of long-term profiles in statin adherence.



Author: Violetta Rozani, Nir Giladi , Baruch El-Ad, Tanya Gurevich, Judith Tsamir, Beatriz Hemo, Chava Peretz

Source: http://plos.srce.hr/



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