Association of the IL-1RN variable number of tandem repeat polymorphism and Helicobacter pylori infection: A meta-analysisReport as inadecuate




Association of the IL-1RN variable number of tandem repeat polymorphism and Helicobacter pylori infection: A meta-analysis - Download this document for free, or read online. Document in PDF available to download.

The aim of this study was to clarify the association of IL-1RN variable number of tandem repeat VNTR polymorphism and H. pylori infection. We performed a meta-analysis of studies retrieved by systematic searches of Pubmed, Embase and the Cochrane Library. Data were analyzed with STATA 13.1 using pooled odds ratios ORs with 95% confidence intervals CIs. A total of 18 studies were included in our meta-analysis, and IL-1RN VNTR was found to be significantly associated with H. pylori infection in the comparisons of 22+2L vs. LL OR = 1.17, 95% CI = 1.02–1.33 and 2 allele vs. L allele OR = 1.18, 95% CI = 1.00–1.40. Stratified analyses on study designs and ethnicities were also conducted. IL-1RN VNTR was positively correlated with H. pylori infection in Asian subgroup and Hospital-Based subgroup i.e., study samples obtained from hospital inpatients. In conclusion, our study demonstrated that IL-1RN VNTR polymorphism might increase the risk of H. pylori infection, especially in Asians.



Author: Jinhua Zhang , Xudong Sun, Jiemin Wang, Fuhua Zhang, Xiaohua Li, Jian Han

Source: http://plos.srce.hr/



DOWNLOAD PDF




Related documents