Comparison of standardized uptake value of 18F-FDG-PET-CT with 21-gene recurrence score in estrogen receptor-positive, HER2-negative breast cancerReport as inadecuate




Comparison of standardized uptake value of 18F-FDG-PET-CT with 21-gene recurrence score in estrogen receptor-positive, HER2-negative breast cancer - Download this document for free, or read online. Document in PDF available to download.

Background

We investigated the relationship between 18F-fluorodeoxyglucose positron emission tomography-computed tomography 18F-FDG-PET-CT standardized uptake value SUV and 21-gene recurrence score RS in estrogen receptor ER-positive-HER2-negative breast cancer.

Materials and methods

One hundred sixty-seven patients were identified among those who underwent preoperative 18F-FDG-PET-CT and had RS. Maximum SUV was obtained from 18F-FDG-PET-CT; the cut-off point was 4.

Results

The continuous RS and SUV correlated positively Pearson’s R = 0.555; P < 0.001. An inverse correlation was found between progesterone receptor PR expression by reverse transcriptase-polymerase chain reaction, and SUV Pearson’s R = -0.408; P < 0.001. Good agreement between dichotomized RS <26 vs. ≥26 and SUV <4 vs. ≥4 was observed in 137 of 167 patients 82.0%; 95% confidence interval CI, 76.2–87.9. Among patients with low SUV, 114 of 115 99.1% 95% CI, 97.4–100.0 had tumors with lower RS <26. Although 23 of 52 women 44.2% 95% CI, 30.7–57.7 with high SUV had higher RS ≥26, all 13 women with high RS ≥31 had high-SUV tumors. Most cases with disagreements between SUV and RS n = 30 were classified as high SUV-lower RS n = 29. The discordant group had higher grade or elevated Ki67 expression ≥20% compared with the low SUV-lower RS group n = 109, but higher PR expression compared with the high SUV-higher RS group n = 23. Multiple logistic regression analysis showed that high SUV were associated with higher RS ≥26.

Conclusions

SUV, as a biologic parameter represented using a continuous variable, was found to associate with RS in ER-positive, HER2-negative breast cancer. Further studies may reveal the biology underlying the discordance between the markers.



Author: Sung Gwe Ahn, Jae-Hoon Lee, Hak Woo Lee, Tae Joo Jeon, Young Hoon Ryu, Kun Min Kim, Joohyuk Sohn, Mijin Yun, Seung Ah Lee, Joon J

Source: http://plos.srce.hr/



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