Association between genotype and drug resistance profiles of Mycobacterium tuberculosis strains circulating in China in a national drug resistance surveyReport as inadecuate




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We describe the population structure of a representative collection of 3,133 Mycobacterium tuberculosis isolates, collected within the framework of a national resistance survey from 2007 in China. Genotyping data indicate that the epidemic strains in China can be divided into seven major complexes, of which 92% belonged to the East Asian mainly Beijing strains or the Euro-American lineage. The epidemic Beijing strains in China are closely related to the Beijing B0-W148 strain earlier described in Russia and a large cluster of these strains has spread national wide. The density of Beijing strains is high in the whole of China average 70%, but the highest prevalence was found North of the Yellow river. The Euro-American lineage consists of three sublineages sublineage 1, 2, and 3 and is more prevalent in the South. Beijing lineage showed the highest cluster rate of 48% and a significantly higher level of resistance to rifampicin 14%, p<0.001, ethambutol 9%, p = 0.001, and ofloxacin 5%, p = 0.011. Within the Euro-American Lineage, sublineage 3 revealed the highest cluster rate 28% and presented a significantly elevated level of resistance to streptomycin 44%, p<0.001. Our findings suggest that standardised treatment in this region may have contributed to the successful spread of certain strains: sublineage 3 in the Euro-American lineage may have thrived when streptomycin was used without rifampicin for treatment, while later under DOTS based treatment, in which rifampicin plays a key role, Beijing lineage appears to be spreading.



Author: Yang Zhou, Susan van den Hof, Shengfen Wang, Yu Pang, Bing Zhao, Hui Xia, Richard Anthony, Xichao Ou, Qiang Li, Yang Zheng, Yuany

Source: http://plos.srce.hr/



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