Prevalence of non-alcoholic fatty liver disease and risk factors for advanced fibrosis and mortality in the United StatesReport as inadecuate




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In the United States, non-alcoholic fatty liver disease NAFLD is the most common liver disease and associated with higher mortality according to data from earlier National Health and Nutrition Examination Survey NHANES 1988–1994. Our goal was to determine the NAFLD prevalence in the recent 1999–2012 NHANES, risk factors for advanced fibrosis stage 3–4 and mortality. NAFLD was defined as having a United States Fatty Liver Index USFLI > 30 in the absence of heavy alcohol use and other known liver diseases. The probability of low-high risk of having advanced fibrosis was determined by the NAFLD Fibrosis Score NFS. In total, 6000 persons were included; of which, 30.0% had NAFLD and 10.3% of these had advanced fibrosis. Five and eight-year overall mortality in NAFLD subjects with advanced fibrosis was significantly higher than subjects without NAFLD 18% and 35% vs. 2.6% and 5.5%, respectively but not NAFLD subjects without advanced fibrosis 1.1% and 2.8%, respectively. NAFLD with advanced fibrosis but not those without is an independent predictor for mortality on multivariate analysis HR = 3.13, 95% CI 1.93–5.08, p<0.001. In conclusion, in this most recent NHANES, NAFLD prevalence remains at 30% with 10.3% of these having advanced fibrosis. NAFLD per se was not a risk factor for increased mortality, but NAFLD with advanced fibrosis was. Mexican American ethnicity was a significant risk factor for NAFLD but not for advanced fibrosis or increased mortality.



Author: Michael H. Le, Pardha Devaki, Nghiem B. Ha, Dae Won Jun, Helen S. Te, Ramsey C. Cheung, Mindie H. Nguyen

Source: http://plos.srce.hr/



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