Targeting mTOR in HIV-Negative Classic Kaposi's SarcomaReport as inadecuate

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SarcomaVolume 2008 2008, Article ID 825093, 4 pages

Case Report

Unit of Bone and Soft Tissue Oncology, Division of Oncology, Tel-Aviv Sourasky Medical Center, 6 Weitzman Street, Tel-Aviv 64239, Israel

Sackler School of Medicine, Tel-Aviv University, Tel-Aviv 64239, Israel

Department of Cell and Developmental Biology, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel

Received 3 November 2007; Accepted 26 February 2008

Academic Editor: Jose Casanova

Copyright © 2008 Ofer Merimsky et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


A 66-year old female with HIV-negative classic Kaposi's sarcoma responded to mTOR targeting by rapamycin. The response was well documented by PET-CT. This case provides supporting evidence that the mTOR pathway may be important in the tumorigenesis of KS and that rapamycin may have activity in this disease.

Author: Ofer Merimsky, Irina Jiveliouk, and Ronit Sagi-Eisenberg



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