Mulberry-extract improves glucose tolerance and decreases insulin concentrations in normoglycaemic adults: Results of a randomised double-blind placebo-controlled studyReport as inadecuate




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Background

High sugar and refined carbohydrate intake is associated with weight gain, increased incidence of diabetes and is linked with increased cardiovascular mortality. Reducing the health impact of poor quality carbohydrate intake is a public health priority. Reducose, a proprietary mulberry leaf extract ME, may reduce blood glucose responses following dietary carbohydrate intake by reducing absorption of glucose from the gut.

Methods

A double-blind, randomised, repeat measure, phase 2 crossover design was used to study the glycaemic and insulinaemic response to one reference product and three test products at the Functional Food Centre, Oxford Brooks University, UK. Participants; 37 adults aged 19–59 years with a BMI ≥ 20kg-m2 and ≤ 30kg-m2. The objective was to determine the effect of three doses of mulberry-extract Reducose versus placebo on blood glucose and insulin responses when co-administered with 50g maltodextrin in normoglycaemic healthy adults. We also report the gastrointestinal tolerability of the mulberry extract.

Results

Thirty-seven participants completed the study: The difference in the positive Incremental Area Under the Curve pIAUC glucose mmol - L x h for half, normal and double dose ME compared with placebo was -6.1% -18.2%, 5.9%; p = 0.316 -14.0% -26.0% -2.0%; p = 0.022 and -22.0% -33.9% -10.0%; p<0.001 respectively. The difference in the pIAUC insulin mIU - L x h for half, normal and double dose ME compared with placebo was -9.7% -25.8%, 6.3%; p = 0.234 -23.8% -39.9% -7.8%; p = 0.004 and -24.7% -40.8% -8.6%; p = 0.003 respectively. There were no statistically significant differences between any of the 4 groups in the odds of experiencing one or more gastrointestinal symptoms nausea, abdominal cramping, distension or flatulence.

Conclusions

Mulberry leaf extract significantly reduces total blood glucose rise after ingestion of maltodextrin over 120 minutes. The pattern of effect demonstrates a classical dose response curve with significant effects over placebo. Importantly, total insulin rises were also significantly suppressed over the same time-period. There were no statistically significant differences between any of the treatment groups including placebo in the odds of experiencing one or more gastrointestinal symptoms. Mulberry extract may have multiple modes of action and further studies are necessary to evaluate ME as a potential target for the prevention of type 2 diabetes and the regulation of dysglycaemia.



Author: Mark Lown , Richard Fuller , Helen Lightowler , Ann Fraser , Andrew Gallagher , Beth Stuart , Christopher Byrne , George Lewith

Source: http://plos.srce.hr/



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