Influence of Cardiorespiratory Fitness on PPARG mRNA Expression Using Monozygotic Twin Case ControlReport as inadecuate




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Journal of Diabetes Research - Volume 2015 2015, Article ID 538732, 7 pages -

Research Article

Departamento de Educação Física da Universidade Estadual do Centro-Oeste UNICENTRO, Rua Simeão Camargo Varela de Sá, 03, 85040-080 Guarapuava, PR, Brazil

Departamento de Educação Física da Universidade Estadual Paulista UNESP, Avenida 24 A 1515, 13506-900 Rio Claro, SP, Brazil

Departamento de Análises Clínicas e Toxicológicas da Universidade Federal do Rio Grande do Norte UFRN, Rua General Gustavo Cordeiro de Farias, 384, 59012-570 Natal, RN, Brazil

Departamento de Análises Clínicas e Toxicológicas da Universidade de São Paulo USP, Avenida Professor Lineu Prestes, 580, 05508-000 São Paulo, SP, Brazil

Received 22 October 2014; Revised 22 February 2015; Accepted 1 March 2015

Academic Editor: Norman Cameron

Copyright © 2015 Marcos Roberto Queiroga et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The influence of cardiorespiratory fitness VO2max on anthropometric variables and PPARG mRNA expression was investigated. Monozygotic twin pairs aged 11–18 years were grouped into discordant D and concordant C high and low VO2max groups. VO2max was determined by progressive maximal exercise test on treadmill with gas exchange analysis. Body mass BM, BMI, waist circumference WC, triceps TR, and subscapular SB skinfold thicknesses were measured. Twins from the discordant group had differences in VO2max values D-high = versus D-low =  mL·kg

·min

, , while no differences were found in the concordant group C-high = versus C-low =  mL·kg

·min

, . In discordant group, VO2max was negatively correlated with TR + SB , and positively correlated with PPARG expression in leukocytes , . Moreover, PPARG expression was directly correlated with BM , and height , . In concordant twins, VO2max was inversely correlated with BM , , BMI , , WC , , and TR + SB , . Twins D-high had 1.78-fold greater PPARG expression when compared with twins D-low . In conclusion, the cardiorespiratory fitness may modulate PPARG expression in childhood and adolescence, independently of the genetic background.





Author: Marcos Roberto Queiroga, Ricardo Augusto Barbieri, Sandra Aires Ferreira, André Ducati Luchessi, Rosario Dominguez Crespo Hir

Source: https://www.hindawi.com/



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