Effect of the different 13-valent pneumococcal conjugate vaccination uptakes on the invasive pneumococcal disease in children: Analysis of a hospital-based and population-based surveillance study in Madrid, Spain, 2007-2015Report as inadecuate




Effect of the different 13-valent pneumococcal conjugate vaccination uptakes on the invasive pneumococcal disease in children: Analysis of a hospital-based and population-based surveillance study in Madrid, Spain, 2007-2015 - Download this document for free, or read online. Document in PDF available to download.

In the Community of Madrid, the 13-valent pneumococcal conjugate vaccine PCV13 replaced the 7-valent PCV7 in the fully government-funded Regional Immunization Program RIP in May, 2010, but was later excluded in May, 2012, and included again in January, 2015. These unique changes allowed us to assess the impact of the different pneumococcal vaccination policies on PCV13 uptake in infants and on the incidence rate IR of invasive pneumococcal disease IPD in children <15 years old. In this prospective, active, surveillance study, we estimated PCV13 uptakes, IR and incidence rate ratios IRR for total IPD and for IPD caused by PCV13- and non-PCV13 serotypes in children <15 years, stratified by age, in four periods with different vaccination policies: fully government-funded PCV7 vaccination, fully government-funded PCV13, mixed public-private funding and only private funding. Vaccine uptakes reached 95% in periods with public-funded pneumococcal vaccination, but fell to 67% in the private funding period. Overall, IR of IPD decreased by 68% p<0.001 in 2014–15, due to 93% reduction in the IR of PCV13-type IPD p<0.001 without significant changes in non-PCV13-type IPD. A fully government-funded PCV13 vaccination program lead to high vaccine uptake and dramatic reductions in both overall and PCV13-type IPD IR. When this program was switched to private PCV13 vaccination, there was a fall in vaccine coverage and stagnation in the decline of PCV13-type IPD with data suggesting a weakening of herd immunity.



Author: Juan Picazo , Jesús Ruiz-Contreras, Juan Casado-Flores, Sagrario Negreira, Fernando Baquero, Teresa Hernández-Sampelayo, Enriqu

Source: http://plos.srce.hr/



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