Effective Prolonged Therapy with Voriconazole in a Lung Transplant Recipient with Spondylodiscitis Induced by Scedosporium apiospermumReport as inadecuate




Effective Prolonged Therapy with Voriconazole in a Lung Transplant Recipient with Spondylodiscitis Induced by Scedosporium apiospermum - Download this document for free, or read online. Document in PDF available to download.

Case Reports in Infectious DiseasesVolume 2011 2011, Article ID 460313, 4 pages

Case Report

Division of Heart and Lungs, Departments of Respiratory Medicine and Lung Transplantation, University Medical Center Utrecht, Heidelberglaan 100, 3584CX Utrecht, The Netherlands

Department of Clinical Microbiology, University Medical Center Utrecht, Utrecht, The Netherlands

Department of Radiology, University Medical Center Utrecht, Utrecht, The Netherlands

Department of Pulmonology, St. Antonius Hospital Nieuwegein, Koekoekslaan 1, 3435CM Nieuwegein, The Netherlands

Received 20 May 2011; Accepted 19 June 2011

Academic Editors: G. J. Casey, K. Chokephaibulkit, A. Marangoni, and M. J. Mimiaga

Copyright © 2011 B. Luijk et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Scedosporium-Pseudallescheria species are frequently seen in cystic fibrosis patients. However, disseminated forms after lung transplantation in these patients are rarely seen, but often with poor outcome. In this case report we describe a lung transplant recipient with cystic fibrosis who developed a spondylodiscitis that was caused by Scedosporium apiospermum. The patient was treated with anti-fungal treatment by voriconazole for over three years with a clinical good response and without the need for surgical intervention. To our opinion this is the first anti-fungal treated case of invasive disease caused by Scedosporium-Pseudallescheria in a cystic fibrosis CF patient who underwent lung transplantation that survived.





Author: B. Luijk, M. B. Ekkelenkamp, P. A. De Jong, J. M. Kwakkel-van Erp, J. C. Grutters, D. A. van Kessel, and E. A. van de Graaf

Source: https://www.hindawi.com/



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