IGF-I and relation to growth in infancy and early childhood in very-low-birth-weight infants and term born infantsReport as inadecuate




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Background

In very-low-birth-weight infants IGF-I plays an important role in postnatal growth restriction and is probably also involved in growth restriction in childhood. We compared IGF-I and its relation to growth in early childhood in very-low-birth-weight infants and term appropriate for gestational age born infants.

Methods

We included 41 very-low-birth-weight and 64 term infants. Anthropometry was performed at all visits to the outpatient clinic. IGF-I and insulin were measured in blood samples taken at 6 months and 2 years corrected age very-low-birth-weight children and at 3 months, 1 and 2 years term children.

Results

Over the first 2 years of life growth parameters are lower in very-low-birth-weight children compared to term children, but the difference in length decreases significantly. During the first 2 years of life IGF-I is higher in very-low-birth-weight children compared to term children. In both groups there is a significant relationship between IGF-I and change in length and weight over the first 2 years of life and between insulin and change in total body fat.

Conclusions

Considering the relation of IGF-I to growth and the decrease in difference in length, higher IGF-I levels in very-low-birth-weight infants in early childhood probably have an important role in catch-up growth in length.



Author: Miranda de Jong, Anneke Cranendonk, Jos W. R. Twisk, Mirjam M. van Weissenbruch

Source: http://plos.srce.hr/



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