Parathyroid Gland Involvement by Thyroid Cancer: Results from a Large Series of Thyroidectomies Performed in Two Italian University Hospitals and Review of the LiteratureReport as inadecuate




Parathyroid Gland Involvement by Thyroid Cancer: Results from a Large Series of Thyroidectomies Performed in Two Italian University Hospitals and Review of the Literature - Download this document for free, or read online. Document in PDF available to download.

Journal of Thyroid Research - Volume 2014 2014, Article ID 685425, 7 pages -

Research Article

Institute of Endocrinology, Catholic University of Rome, 00168 Rome, Italy

Institute of Anatomic Pathology, University of Modena and Reggio Emilia, 41100 Modena, Italy

Institute of Anatomic Pathology, Catholic University of Rome, 00168 Rome, Italy

Received 4 August 2014; Accepted 18 October 2014; Published 11 November 2014

Academic Editor: Brendan C. Stack Jr.

Copyright © 2014 Giampaolo Papi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objectives.Parathyroid involvement by thyroid cancer TC has not been frequently investigated in thyroidectomy-based studies. We aimed to detect cases of parathyroid invasion by TC in a large series of thyroidectomies and to review the literature on this topic. Study Design. A 10-yr period database research was made from the files of the Section of Pathology of two Italian University Hospitals. Out of 22,310 thyroidectomies, 10 patients with parathyroid involvement by TC were found. Results. The 10 patients, 7 females and 3 males, aged years range 34–76, median 56 had papillary thyroid carcinoma and accounted for 0.4% of subjects affected by all TCs and submitted to thyroidectomy. The tumor invaded perithyroid soft tissues in 6 patients and central neck level VI lymph nodes in 3. Parathyroid involvement by TC occurred by infiltration in 6 cases, extension through an intervening pseudocapsule in 1, and both patterns in 3. All patients are alive and disease free at -yr follow-up. Conclusion. Limited to thyroidectomy series, our results and literature data suggest that parathyroid involvement by TC has a 0.4–3.9% incidence rate; mainly affects women in their sixth-seventh decade of life; is associated to a good prognosis, unless massive extrathyroid extension of TC occurs.





Author: Giampaolo Papi, Stefania Corrado, Guido Fadda, Antonino Maiorana, Livia Maccio, Salvatore Maria Corsello, and Alfredo Pontec

Source: https://www.hindawi.com/



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