Vitamin D deficiency is significantly associated with depression in patients with chronic kidney diseaseReport as inadecuate




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Background

Depression is reported to be the most common psychological problem in patients with chronic kidney disease CKD. Several studies have reported that lower levels of serum vitamin D are significantly associated with depression. Both vitamin D deficiency and depression are prevalent in patients with CKD, yet the relationship between these two factors remains poorly understood. This study aimed to investigate the association between vitamin D levels and depression among CKD patients.

Methods

Totally, 21,257 individuals who participated in the Korean National Health and Nutrition Examination Survey KNHANES V, VI from 2010–2014 were screened for the study; 533 CKD patients were included. Vitamin D deficiency was defined as serum 25-hydroxyvitamin D3 25OHD3 ≤10 ng-mL. Patients were divided into vitamin D deficient or sufficient groups. Depression was screened for using the Korean version of the WHO Composite International Diagnostic Interview-Short Form. The association between vitamin D deficiency and depression was evaluated by multivariate logistic regression analysis.

Results

The mean participant age was 70.1±9.4 years; 262 patients 49.2% were male. The median 25OHD3 level was 19.1±6.9 ng-mL. The prevalence of depression was higher in CKD patients than in the general population 14.3 vs. 11.1%, P = 0.03. Additionally, the prevalence of depression was significantly higher in CKD patients with vs. without vitamin D deficiency 32.5% vs. 50.0%, P<0.001. Multivariate logistic regression analysis showed that vitamin D deficiency was a significant independent predictor of depression after adjusting for confounding factors adjusted odds ratio, 6.15; 95% confidence interval, 2.02–8.75; P = 0.001.

Conclusion

Depression was highly prevalent in CKD patients, in whom vitamin D deficiency was a significant independent predictor of depression. Therefore, management of vitamin D deficiency might help prevent depression in CKD patients.



Author: Jong Hyun Jhee, Hyoungnae Kim, Seohyun Park, Hae-Ryong Yun, Su-Young Jung, Youn Kyung Kee, Chang-Yun Yoon, Jung Tak Park, Seung H

Source: http://plos.srce.hr/



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