Identification of the Molecular Clockwork of the Oyster Crassostrea gigasReport as inadecuate




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Molecular clock system constitutes the origin of biological rhythms that allow organisms to anticipate cyclic environmental changes and adapt their behavior and physiology. Components of the molecular clock are largely conserved across a broad range of species but appreciable diversity in clock structure and function is also present especially in invertebrates. The present work aimed at identify and characterize molecular clockwork components in relationship with the monitoring of valve activity behavior in the oyster Crassostrea gigas. Results provided the characterization of most of canonical clock gene including clock, bmal-cycle, period, timeless, vertebrate-type cry, rev-erb, ror as well as other members of the cryptochrome-photolyase family plant-like cry, 6–4 photolyase. Analyses of transcriptional variations of clock candidates in oysters exposed to light - dark regime and to constant darkness led to the generation of a putative and original clockwork model in C. gigas, intermediate of described systems in vertebrates and insects. This study is the first characterization of a mollusk clockwork. It constitutes essential bases to understand interactions of the different components of the molecular clock in C. gigas as well as the global mechanisms associated to the generation and the synchronization of biological rhythms in oysters.



Author: Mickael Perrigault , Damien Tran

Source: http://plos.srce.hr/



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