MTHFR C677T, A1298C and MS A2756G Gene Polymorphisms and Male Infertility Risk in a Chinese Population: A Meta-AnalysisReport as inadecuate




MTHFR C677T, A1298C and MS A2756G Gene Polymorphisms and Male Infertility Risk in a Chinese Population: A Meta-Analysis - Download this document for free, or read online. Document in PDF available to download.

Background

Methylenetetrahydrofolate reductase gene MTHFR C677T and A1298C and methionine synthase gene MS A2756G polymorphisms have shown an association with male infertility risk in several ethnic populations. Although several studies have evaluated these associations in Chinese populations, their small sample sizes and inconsistent outcomes have prevented strong conclusions. Therefore, the present meta-analysis was performed with published studies to evaluate the associations of the three single nucleotide polymorphisms SNPs and male infertility in a Chinese population.

Methods

We conducted a search of PubMed, Embase, Web of Science, Chinese National Knowledge Infrastructure CNKI, China biology medical literature CBM, VIP, and Chinese literature Wan Fang databases up to May 31, 2016. Odds ratios ORs and 95% confidence intervals 95%CIs were used to assess the strength of associations with a random-effect model or a fixed-effect model based on the heterogeneity analysis results. Sensitivity analysis was used to confirm the reliability and stability of the meta-analysis.

Results

A total of nine studies, including 1,713 cases and 1,104 controls, were included in the meta-analysis. The pooled results indicated that the MTHFR C667T polymorphism was significantly associated with increased risk of male infertility in the Chinese population in the allele model T vs. C: OR = 1.47, 95%CI = 1.32–1.63, the dominant model TT + CT vs. CC: OR = 1.51, 95%CI = 1.30–1.77, the additive model TT vs. CC: OR = 2.08, 95%CI = 1.68–2.58 and the recessive model TT vs. CT+CC: OR = 1.58, 95%CI = 1.31–1.90, whereas the MTHFR A1298C and MS A2756G polymorphisms were not risk factors. There was no significant heterogeneity in any genotype contrasts among the studies. The sensitivity analysis indicated that the results of this meta-analysis were relatively stable.

Conclusion

This study suggests that the MTHFR C667T polymorphism may contribute to the genetic susceptibility to male infertility in the Chinese population, whereas MTHFR A1298C and MS A2756G polymorphisms may be unrelated to male infertility. Studies with larger sample sizes and representative population-based cases and well-matched controls are needed to validate our results.



Author: Zhengju Ren , Pengwei Ren , Bo Yang, Kun Fang, Shangqing Ren, Jian Liao, Shengzhuo Liu, Liangren Liu, Zhufeng Peng, Qiang Dong

Source: http://plos.srce.hr/



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