Distinct and Shared Endophenotypes of Neural Substrates in Bipolar and Major Depressive DisordersReport as inadecuate




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Little is known about disorder-specific biomarkers of bipolar disorder BD and major depressive disorder MDD. Our aim was to determine a neural substrate that could be used to distinguish BD from MDD. Our study included a BD group 10 patients with BD, 10 first-degree relatives FDRs of individuals with BD, MDD group 17 patients with MDD, 17 FDRs of individuals with MDD, and 27 healthy individuals. Structural and functional brain abnormalities were evaluated by voxel-based morphometry and a trail making test TMT, respectively. The BD group showed a significant main effect of diagnosis in the gray matter GM volume of the anterior cingulate cortex ACC; p = 0.01 and left insula p < 0.01. FDRs of individuals with BD showed significantly smaller left ACC GM volume than healthy subjects p < 0.01, and patients with BD showed significantly smaller ACC p < 0.01 and left insular GM volume p < 0.01 than healthy subjects. The MDD group showed a tendency toward a main effect of diagnosis in the right and left insular GM volume. The BD group showed a significantly inverse correlation between the left insular GM volume and TMT-A scores p < 0.05. Our results suggest that the ACC volume could be a distinct endophenotype of BD, while the insular volume could be a shared BD and MDD endophenotype. Moreover, the insula could be associated with cognitive decline and poor outcome in BD.



Author: Toshio Matsubara, Koji Matsuo , Kenichiro Harada, Masayuki Nakano, Mami Nakashima, Toshio Watanuki, Kazuteru Egashira, Matakazu F

Source: http://plos.srce.hr/



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