Platelets miRNA as a Prediction Marker of Thrombotic EpisodesReport as inadecuate




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Disease Markers - Volume 2016 2016, Article ID 2872507, 7 pages -

Review Article

Department of General Biochemistry, Faculty of Biology and Environmental Protection, University of Lodz, Pomorska 141-143, 90-236 Lodz, Poland

Intensive Cardiac Therapy Clinic, Medical University of Lodz, Pomorska 251, 91-213 Lodz, Poland

Received 25 July 2016; Accepted 4 October 2016

Academic Editor: Kailash Gulshan

Copyright © 2016 Michal Bijak et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The blood platelets are crucial for the coagulation physiology to maintain haemostatic balance and are involved in various pathologies such as atherosclerosis and thrombosis. The studies of recent years have shown that anucleated platelets are able to succeed protein synthesis. Additionally, mRNA translation in blood platelets is regulated by miRNA molecules. Recent works postulate the possibility of using miRNAs as biomarkers of atherosclerosis and ischemic episodes. This review article describes clinical studies that presented blood platelets miRNAs expression profile changes in different thrombotic states, which suggest use of these molecules as predictive biomarkers.





Author: Michal Bijak, Malgorzata Dzieciol, Joanna Rywaniak, Joanna Saluk, and Marzenna Zielinska

Source: https://www.hindawi.com/



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