Vascular Complications of Systemic Sclerosis during PregnancyReport as inadecuate




Vascular Complications of Systemic Sclerosis during Pregnancy - Download this document for free, or read online. Document in PDF available to download.

International Journal of RheumatologyVolume 2010 2010, Article ID 287248, 5 pages

Review ArticleDivision of Immunology and Rheumatology, Stanford University School of Medicine, 1000 Welch Road, Suite 203, Palo Alto, CA 94304, USA

Received 15 April 2010; Accepted 2 July 2010

Academic Editor: Virginia D. Steen

Copyright © 2010 Eliza F. Chakravarty. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Systemic sclerosis SSc is a chronic autoimmune disorder characterized by progressive fibrosis of the skin and visceral tissues as well as a noninflammatory vasculopathy. Vascular disease in systemic sclerosis is a major cause of morbidity and mortality among nonpregnant patients with SSc and is even a bigger concern in the pregnant SSc patient, as the underlying vasculopathy may prevent the required hemodynamic changes necessary to support a growing pregnancy. Vascular manifestations including scleroderma renal crisis and pulmonary arterial hypertension should be considered relative contraindications against pregnancy due to the high associations of both maternal and fetal morbidity and mortality. In contrast, Raynaud-s phenomenon may actually improve somewhat during pregnancy. Women with SSc who are considering a pregnancy or discover they are pregnant require evaluation for the presence and extent of underlying vasculopathy. In the absence of significant visceral vasculopathy, most women with SSc can expect to have reasonable pregnancy outcomes.





Author: Eliza F. Chakravarty

Source: https://www.hindawi.com/



DOWNLOAD PDF




Related documents